There is no one answer for this question but from my experience if you really want to get rid of your acne there are two recommended solutions that should combined together (if you can afford it) for best results.

Firstly and more important in my opinion, you must learn how you should fix the internal problem that’s causing your acne, not just masking the symptoms or getting relief.
There are only few good Ebooks and acne cure programs that can teach you exactly how to treat your acne from the inside.

Where medicine has failed them the authors have done their own research and found a way to overcome acne. In their books they share their great knowledge with other acne sufferers. Anyhow, be very careful because many of them are pure crap with little value.

You can find helpful and honest review about one of the best systems today in this great article:

http://www.squidoo.com/Acne-No-More-Ebook-Review

The second thing that you need to do is to get good acne skin product that will be suitable for your skin.
There are hundreds of acne skin care products available in the market right now and it’s not easy to choose the product that will give you the best results.
When choosing your product make sure to check that you get at least 2 months full guarantee. Some of the big names in the industry are:
ClearPores, Acuzine, Acnezine, Proactiv, Vilante and some others.
If you are in a short budget Acnezine can be a great choice for you because they offer free trial of their acne treatment system and also full guarantee. You can find more on their limited time free trial offer here:

http://www.freeacnezine.info

I hope that these tips will be helpful for you
References :

I have tried many, many different products to improve my acne/acne scars. All have failed. And Proactive did not work either

I eat healthy, and I exercise often, but I still have bad acne.

Are there any good reviews on what is working out there?